nginx Common Issues
upstream sent too big header while reading response header from upstream
Direct Servicing Content
Change your fastcgi buffers
fastcgi_buffers 16 24k; fastcgi_buffer_size 128k;
as Proxy
Change your proxy buffers
proxy_buffers 16 24k; proxy_buffer_size 128k; proxy_busy_buffers_size 128k;
In both cases try to find the appropriate buffer size, the sizes posted here are for illustration purposes but should work in 80% of cases.
Also note that in case of long polling services you should turn off the proxy buffers using:
proxy_buffering off;